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KMID : 0545120090190121569
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Journal of Microbiology and Biotechnology
2009 Volume.19 No. 12 p.1569 ~ p.1572
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Absorption, Distribution, Metabolism, and Excretion of Decursin and Decursinol angelate from Angelica gigas Nakai
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Kim Kang-Min
Kim Myo-Jeong
Kang Jae-Seon
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Abstract
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The pharmacokinetics of decursin and decursinol angelate (D/DA) was investigated in male SD rats following oral and intravenous administration. D/DA and metabolites obtained from in vitro samples were evaluated by LC/MS. The level of D/DA and metabolized decursinol in the blood following oral and intravenous administration declined according to first-order kinetics, with T1/2 values of 56.67, 58.01 and 57.22 h, respectively, being observed after administration of a dose of 2 mg/kg body weight. The large intestine was the major site of disposition following oral administration. These data indicate that D/DA is rapidly absorbed from the gastrointestinal tract. In in vitro experiment utilizing liver microsomal protein, the major metabolic reaction of D/DA occurred to change decursinol. The cumulative biliary, urinary, and fecal excretion of D/DA in bile duct-cannulated rats was 36.10 ± 2.9, 25.35 ± 3.8, and 34.20 ± 3.2%, respectively, at 72 h after administration. These results indicate that the absorption of D/DA is almost complete, and that its metabolites are primarily excreted into feces through the bile. These results indicate that D/DA is subject to enterohepatic circulation.
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KEYWORD
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Pharmacokinetics, Decursin, Decursinol angelate, Metabolism, Angelica gigas Nakai
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